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Article

Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway.

Genes & development - 15 Dec 2013

Lee Kyu-Sun, Wu Zhihao, Song Yan, Mitra Siddhartha S, Feroze Abdullah H, Cheshier Samuel H, Lu Bingwei

Abstract excerpt

The self-renewal versus differentiation choice of Drosophila and mammalian neural stem cells (NSCs) requires Notch (N) signaling. How N regulates NSC behavior is not well understood. Here we show that canonical N signaling cooperates with a noncanonical N signaling pathway to mediate N-directed NSC regulation. In the noncanonical pathway, N interacts with PTEN-induced kinase 1 (PINK1) to influence mitochondrial...

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Source

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Identifiers

PMID: 24352421
DOI: 10.1101/gad.225169.113
PMCID: PMC3877754

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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