Article

Identification of new KCNT1-epilepsy drugs by <i>in silico,</i> cell and <i>Drosophila</i> modelling

2025-05-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Hyperactive KCNT1 potassium channels, caused by gain-of-function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug-resistant seizures and in cases with infantile onset, developmental regression can follow. KCNT1-related disorders include epilepsy of infancy with migrating focal seizures and sleep related hypermotor epilepsy. Ther...

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Literature Corpus work: 9a01408e-19cb-5962-ae0a-befeaf910a4f
DOI: 10.1101/2025.05.22.655336

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