Article

Modelling human KCNT1-epilepsy in <i>Drosophila</i> : a seizure phenotype and drug responses

2023-04-12

Abstract excerpt

Mutations in the KCNT1 potassium channel cause severe forms of epilepsy which are resistant to current treatments. In vitro studies have shown that KCNT1- epilepsy mutations are gain of function, significantly increasing K + current amplitudes. To investigate if Drosophila can be used to model human KCNT1 epilepsy, we generated Drosophila melanogaster lines carrying human KCNT1 with the patient mutation G2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4e2f5ca4-db47-51d3-bbab-547f96b510e6
DOI: 10.1101/2023.04.11.536495

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modelling human KCNT1-epilepsy in <i>Drosophila</i> : a seizure phenotype and drug responsesDOI 10.1101/2023.04.11.536495Read

Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy.Semantic proximity Read

Identification of new KCNT1-epilepsy drugs by <i>in silico,</i> cell and <i>Drosophila</i> modellingSemantic proximity Read

From bench to drug: human seizure modeling using Drosophila.Semantic proximity Read

Identification of New KCNT1-Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling.Semantic proximity Read

Seizure-suppressor genes: can they help spearhead the discovery of novel therapeutic targets for epilepsy?Semantic proximity Read

A Zebrafish Platform to Model Human <i>SCN2A</i> and <i>SCN8A</i> Epilepsy and Evaluate Anti-Seizure MedicationsSemantic proximity Read

Model systems for studying cellular mechanisms of SCN1A-related epilepsy.Semantic proximity Read

Approaches for the discovery of drugs that target K Na 1.1 channels in KCNT1-associated epilepsy.Semantic proximity Read

Uncovering functional insights into human pathogenic variants in <i>CDK19</i> using Drosophila modelsSemantic proximity Read

Seizure and epilepsy: studies of seizure disorders in Drosophila.Semantic proximity Read

Seizures, behavioral deficits and adverse drug responses in two new genetic mouse models of <i>HCN1</i> epileptic encephalopathySemantic proximity Read

The Interaction of <i>UBR4, LRP1</i> , and <i>OPHN1</i> in Refractory Epilepsy: <i>Drosophila</i> Model to Investigate the Oligogenic Effect on EpilepsySemantic proximity Read