Article

A Zebrafish Platform to Model Human <i>SCN2A</i> and <i>SCN8A</i> Epilepsy and Evaluate Anti-Seizure Medications

2026-06-25

Abstract excerpt

Many patients with epilepsy have inadequate seizure control using current anti-seizure medications (ASMs), illustrating the need for new treatments. Genetic epilepsy syndromes like pathogenic variants in voltage gated sodium channel SCN2A and SCN8A are often poorly controlled by current medications, highlighting the need for better models. Voltage gated sodium channel pathogenic variants that induce epilepsy are...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 222e527a-f675-5b74-b0da-a04908d1a9c8
DOI: 10.64898/2026.06.21.733632

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Zebrafish Platform to Model Human <i>SCN2A</i> and <i>SCN8A</i> Epilepsy and Evaluate Anti-Seizure MedicationsDOI 10.64898/2026.06.21.733632Read

Advancing epilepsy treatment through personalized genetic zebrafish models.Semantic proximity Read

Seizure Semiology and Response to Treatment in a Pediatric Cohort with<i>SCN2A</i>Variants: A Parent ReportSemantic proximity Read

Mutant zebrafish lacking slc25a22a show spontaneous seizures and respond to the anti-seizure medication valproic acid.Semantic proximity Read

Development of an Antiseizure Drug Screening Platform for Dravet Syndrome at the NINDS contract site for the Epilepsy Therapy Screening ProgramSemantic proximity Read

Building a zebrafish toolkit for investigating the pathobiology of epilepsy and identifying new treatments for epileptic seizures.Semantic proximity Read

Phenotypic analysis of catastrophic childhood epilepsy genes: The Epilepsy Zebrafish ProjectSemantic proximity Read

Testing of putative antiseizure drugs in a preclinical Dravet syndrome zebrafish modelSemantic proximity Read

Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitabilitySemantic proximity Read

Toward the use of novel alternative methods in epilepsy modeling and drug discoverySemantic proximity Read

Cenobamate as add-on treatment for<i>SCN8A</i>developmental and epileptic encephalopathySemantic proximity Read

Testing of putative antiseizure medications in a preclinical Dravet syndrome zebrafish modelSemantic proximity Read

Base Editing Rescue of Seizures and SUDEP in <i>SCN8A</i> Developmental Epileptic EncephalopathySemantic proximity Read