Article
Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy.
Scientific reports - 9 Feb 2024
Hussain Rashid, Lim Chiao Xin, Shaukat Zeeshan, Islam Anowarul, Caseley Emily A, Lippiat Jonathan D, Rychkov Grigori Y, Ricos Michael G, Dibbens Leanne M
Abstract excerpt
Mutations in the KCNT1 potassium channel cause severe forms of epilepsy which are poorly controlled with current treatments. In vitro studies have shown that KCNT1-epilepsy mutations are gain of function, significantly increasing K+ current amplitudes. To investigate if Drosophila can be used to model human KCNT1 epilepsy, we generated Drosophila melanogaster lines carrying human KCNT1 with the patient mutation...
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