Article

Current Landscape and the Potential Role of HIF and Selenium in Clear Cell Renal Cell Carcinoma Treatment

2018-09-19

Abstract excerpt

In the last two decades, the discovery of various pathways involved in renal cell carcinoma (RCC) have led to the development of biologically-driven targeted therapies. Hypoxia inducible factors (HIFs), angiogenic growth factors, von Hippel-Lindau (VHL) gene mutations and oncogenic miRNAs play essential roles in the pathogenesis and drug resistance of clear cell renal cell carcinoma. These insights have led to the...

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Literature Corpus work: 2dfc79eb-299f-52ef-82e1-050db4fc6f6c
DOI: 10.20944/preprints201809.0364.v1

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