Article

Effects of Early General Anesthetic Exposure on Susceptibility to Chronic Pain by Enhancement of Neural Activity via Mammalian Target of Rapamycin Pathway

2023-08-10

Abstract excerpt

Patients who have undergone surgery in early life may be at elevated risk for neuropathic pain in later life. The risk factors for this susceptibility are not fully understood. Here, we used a mouse chronic pain model to test the hypothesis that early exposure to general anesthetic (GA) causes cellular and molecular alterations in dorsal spinal cord (DSC) and dorsal root ganglion (DRG) that produces a predispositi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99ec815e-c122-5e58-8281-8feafc25e849
DOI: 10.20944/preprints202308.0796.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of Early General Anesthetic Exposure on Susceptibility to Chronic Pain by Enhancement of Neural Activity via Mammalian Target of Rapamycin PathwayDOI 10.20944/preprints202308.0796.v1Read

Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR PathwaySemantic proximity Read

Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational ProfilingSemantic proximity Read

A Novel Mouse Model of Chronic Primary Pain Conditions that Integrates Clinically Relevant Genetic and Environmental FactorsSemantic proximity Read

Effects of Sevoflurane on the Development of a Human Brain Microphysiological SystemSemantic proximity Read

Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidenceSemantic proximity Read

The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complexSemantic proximity Read

Chronic postnatal chemogenetic activation of forebrain excitatory neurons modulates adult glial function and metabolism in male miceSemantic proximity Read

The genetics of isoflurane-induced developmental neurotoxicity.Semantic proximity Read

Repetitive and compulsive behavior after Early-Life-Pain in miceSemantic proximity Read

The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns.Semantic proximity Read

Conditional <i>Lpar1</i> gene targeting identifies cell types mediating neuropathic painSemantic proximity Read

Early Life Stress induces brain-wide electrical network predisposition to migraineSemantic proximity Read