Article

Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway

2018-06-06

Abstract excerpt

Human epidemiologic studies and laboratory investigations in animal models suggest that exposure to general anesthetic agents (GAs) have harmful effects on brain development. The mechanism underlying this putative iatrogenic condition is not clear and there are currently no accepted strategies for prophylaxis or treatment. Recent evidence suggests that anesthetics might cause persistent deficits in synaptogenesis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 97f1ce24-5768-5124-a053-41bc50402da4
DOI: 10.20944/preprints201806.0083.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR PathwayDOI 10.20944/preprints201806.0083.v1Read

TSC-mTORC1 Pathway in Postnatal V-SVZ NeurodevelopmentSemantic proximity Read

Effects of Sevoflurane on the Development of a Human Brain Microphysiological SystemSemantic proximity Read

Effects of Early General Anesthetic Exposure on Susceptibility to Chronic Pain by Enhancement of Neural Activity via Mammalian Target of Rapamycin PathwaySemantic proximity Read

mTOR inhibitors in the pharmacologic management of tuberous sclerosis complex and their potential role in other rare neurodevelopmental disordersSemantic proximity Read

Developmental Characterization of Neuronal Migration Anomalies and Axon Proliferation in mTOR pathway-associated Malformations of Cortical DevelopmentSemantic proximity Read

Tanc2-dependent direct and regulated mTOR inhibition balances mTORC1/2 signaling in developing mouse and human neuronsSemantic proximity Read

mTOR signaling in epilepsy: insights from malformations of cortical development.Semantic proximity Read

mTOR and epileptogenesis in developmental brain malformationsSemantic proximity Read

The differential effects of prenatal and/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complexSemantic proximity Read

mTOR driven gene transcription is required for cholesterol production in neurons of the developing cerebral cortexSemantic proximity Read

Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in uteroSemantic proximity Read

mTOR: A pathogenic signaling pathway in developmental brain malformations.Semantic proximity Read