Article

Chronic postnatal chemogenetic activation of forebrain excitatory neurons modulates adult glial function and metabolism in male mice

2026-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Early adversity increases vulnerability for adult psychopathology. Across multiple pre-clinical models of early adversity, there are reports of glial dysfunction and disrupted amino acid neurotransmission, along with maladaptive behavioral responses in adulthood. Disrupted G-protein coupled receptor signaling is known to phenocopy specific consequences of early life adversity. Enhanced Gq signal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e4532cc7-1de8-56bb-b152-bd98b269553b
DOI: 10.64898/2026.05.16.725656

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chronic postnatal chemogenetic activation of forebrain excitatory neurons modulates adult glial function and metabolism in male miceDOI 10.64898/2026.05.16.725656Read

Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle poolsSemantic proximity Read

Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP miceSemantic proximity Read

Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2–neuronal FGFR1 axisSemantic proximity Read

Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure.Semantic proximity Read

Hypoxia-Ischemia During a Neonatal Sensitive Period Alters Purkinje Neuron Dendritic Complexity Differently in Male and Female RatsSemantic proximity Read

Prenatal ethanol exposure impairs hippocampal plasticity and cognition in adolescent miceSemantic proximity Read

A ketogenic diet mitigates hippocampal astrogliosis in epileptic brainSemantic proximity Read

Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effectsSemantic proximity Read

Developmental Bioenergetic Reprogramming and Glycolytic Shift in Schizophrenia VulnerabilitySemantic proximity Read

Physiological and pathophysiological roles of excitatory amino acids during central nervous system developmentSemantic proximity Read

Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus.Semantic proximity Read

( <i>R,S</i> )-ketamine’s rapid-acting antidepressant effects are modulated by NR2B-containing NMDA receptors on adult-born hippocampal neuronsSemantic proximity Read