Article

Nitric oxide S-nitrosylates CSF1R to augment the action of CSF1R inhibition against castration resistant prostate cancer

2022-06-11

Abstract excerpt

During progression of prostate cancer, sustained oxidative overload in cancer cells potentiates the overall tumor microenvironment (TME). Targeting the TME using colony-stimulating factor 1 receptor (CSF1R) inhibition is a promising therapy for castration-resistant prostate cancer (CRPC). However, the therapeutic response to sustained CSF1R blockade therapy (CSF1Ri) is limited as a monotherapy. We postulated that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99e7e7bd-be88-5ca6-a5a6-f50b12127126
DOI: 10.1101/2022.06.09.495543

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nitric oxide S-nitrosylates CSF1R to augment the action of CSF1R inhibition against castration resistant prostate cancerDOI 10.1101/2022.06.09.495543Read

S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against Prostate cancerSemantic proximity Read

S-nitrosoglutathione Inhibits the Growth of Androgen-Receptor Dependent and Castration Resistant Prostate Cancer by Modulating FOXM1 SignalingSemantic proximity Read

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast CancerSemantic proximity Read

GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylationSemantic proximity Read

The Role of Nitric Oxide in Cancer: Master Regulator or NOt?Semantic proximity Read

S-Nitrosylation of the epidermal growth factor receptor: a regulatory mechanism of receptor tyrosine kinase activity.Semantic proximity Read

Nitric Oxide: Perspectives and Emerging Studies of a Well Known CytotoxinSemantic proximity Read

Inhibition of Epithelial-to-Mesenchymal Transition (EMT) in Cancer by Nitric Oxide: Pivotal Roles of Nitrosylation of NF-κB, YY1 and SnailSemantic proximity Read

Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1.Semantic proximity Read

Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype.Semantic proximity Read

The multifaceted roles of nitric oxide in cancerSemantic proximity Read

Effects of ERK1/2 S-nitrosylation on ERK1/2 phosphorylation and cell survival in glioma cells.Semantic proximity Read