Article

S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against Prostate cancer

2022-08-01

Abstract excerpt

<title>Abstract</title> <p>Sustained oxidative overload in castration-resistant prostate cancer (CRPC) cells potentiates the overall tumor microenvironment (TME). Targeting the TME using colony-stimulating factor 1 receptor (CSF1R) inhibition is a promising therapy for CRPC. However, the therapeutic response to sustained CSF1R blockade therapy (CSF1Ri) is limited as a monotherapy. We postulated that one of the ca...

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Literature Corpus work: d0830fbe-d42f-5b14-be74-34e7922252b9
DOI: 10.21203/rs.3.rs-1833388/v1

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