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Article

Molecular basis of polycomb group protein-mediated fetal hemoglobin repression

9 Mar 2023

Abstract excerpt

The switch from fetal hemoglobin (HbF) to adult hemoglobin (HbA) is a paradigm for developmental gene expression control with relevance to sickle cell disease and β-thalassemia. Polycomb repressive complex (PRC) proteins regulate this switch, and an inhibitor of PRC2 has entered a clinical trial for HbF activation. Yet, how PRC complexes function in this process, their target genes, and relevant subunit...

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PMID: 36893455
DOI: 10.1182/blood.2022019578

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