Article

The immunogenic potential of recurrent cancer drug resistance mutations: an <i>in silico</i> study

2019-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Cancer somatic mutations have been identified as a source of antigens that can be targeted by cancer immunotherapy. In this work, expanding on previous studies, we analyse the immunogenic properties of mutations that are known to drive resistance to cancer targeted-therapies. We survey a large dataset of mutations that confer resistance to different drugs and occur in numerous genes and tumour t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 996f71a6-0d29-58fd-893c-2e9ee41296bd
DOI: 10.1101/845784

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The immunogenic potential of recurrent cancer drug resistance mutations: an <i>in silico</i> studyDOI 10.1101/845784Read

The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.Semantic proximity Read

Identification and Ranking of Recurrent Neo-Epitopes in CancerSemantic proximity Read

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors.Semantic proximity Read

Identification and ranking of recurrent neo-epitopes in cancer.Semantic proximity Read

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumorsSemantic proximity Read

A census of predicted mutational epitopes suitable for immunologic cancer control.Semantic proximity Read

Impact of Human Genetic Variation Underlying Resistance to Antigen-Specific ImmunotherapySemantic proximity Read

Targeting cancer-specific mutations by T cell receptor gene therapy.Semantic proximity Read

Recurrent Neoantigens in Colorectal Cancer as Potential Immunotherapy TargetsSemantic proximity Read

'Final common pathway' of human cancer immunotherapy: targeting random somatic mutationsSemantic proximity Read

Variable Mutation Expression in Human Cancers: A "Hide-and-Seek" Mechanism Linked to Differential MHC-I Presentation Dynamics.Semantic proximity Read

Quantifying Immune-Based Counterselection of Somatic MutationsSemantic proximity Read