Article

Activation of the cGAS-STING pathway mediated by Irgm1 contributes to the development of restrictive cardiomyopathy induced by cTnIR193H mutation

2025-04-04

Abstract excerpt

<title>Abstract</title> Restrictive cardiomyopathy (RCM) is a rare, fatal disorder that rapidly progresses in children. TNNI3 mutations represent the most common genetic cause. Although cTnI mutations are known to increase myofilament calcium sensitivity and impair diastolic function, this mechanism alone does not fully account for disease pathogenesis. Recent studies have revealed that the immune system plays...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9961d2af-08a7-5490-9948-5e9c42ad4f67
DOI: 10.21203/rs.3.rs-6200397/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Activation of the cGAS-STING pathway mediated by Irgm1 contributes to the development of restrictive cardiomyopathy induced by cTnIR193H mutationDOI 10.21203/rs.3.rs-6200397/v1Read

The cGAS/STING Pathway: Friend or Foe in Regulating CardiomyopathySemantic proximity Read

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndromeSemantic proximity Read

Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy miceSemantic proximity Read

MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosisSemantic proximity Read

Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome.Semantic proximity Read

Haematopoietic loss of KDM6A impairs cardiac recovery in heart failure via epigenetic reprogramming of myeloid cellsSemantic proximity Read

Mechanisms of Innate Immune Injury in Arrhythmogenic CardiomyopathySemantic proximity Read

Investigating the Profile of Patients with Idiopathic Inflammatory Myopathies in the Post-COVID-19 Period: Emphasizing Myocardial InjurySemantic proximity Read

MATRIN3 deficiency triggers autoinflammation via cGAS-STING activationSemantic proximity Read

A novel S100A-TLR3-IFIT3 signaling axis promotes cardiomyocyte apoptosis during myocardial infarctionSemantic proximity Read

A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated MyocarditisSemantic proximity Read

PiRNA CFAPIR inhibits cardiac fibrosis by regulating the muscleblind-like protein MBNL2Semantic proximity Read