Article

PINT: Pathway-pathway interactions for predicting interpretable clinical outcomes from gene expression

2026-08-17

Abstract excerpt

<h4>Motivation</h4> Disease mechanisms emerge from the coordinated activity of multiple biological pathways, rather than from individual pathways acting in isolation. Existing pathway-based deep learning models, however, treat pathways as independent entities, aggregating their representations through fully connected layers that disregard inter-pathway relationships. This architectural limitation overlooks an imp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 994adb58-73bd-5bd0-83c0-0b38a1576131
DOI: 10.64898/2026.08.11.744286

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PINT: Pathway-pathway interactions for predicting interpretable clinical outcomes from gene expressionDOI 10.64898/2026.08.11.744286Read

Cancer subtype classification and modeling by pathway attention and propagationSemantic proximity Read

PathX-CNN: An Enhanced Explainable Convolutional Neural Network for Survival Prediction and Pathway Analysis in GlioblastomaSemantic proximity Read

Development of Biologically Interpretable Multimodal Deep Learning Model for Cancer Prognosis PredictionSemantic proximity Read

Revealing the impact of genomic alterations on cancer cell signaling with a partially transparent deep learning modelSemantic proximity Read

GPS-Net: discovering prognostic pathway modules based on network regularized kernel learningSemantic proximity Read

PathHDNN: a pathway hierarchical-informed deep neural network framework for predicting immunotherapy response and mechanism interpretation.Semantic proximity Read

PathCLAST: Pathway-Augmented Contrastive Learning with Attention for Spatial TranscriptomicsSemantic proximity Read

PathExpSurv: Pathway Expansion for Explainable Survival Analysis and Disease Gene DiscoverySemantic proximity Read

PIMO: Pathway-based Interpretable Multi-Omics interactions for multi-omics integrationSemantic proximity Read

PINNet: a deep neural network with pathway prior knowledge for Alzheimer's diseaseSemantic proximity Read

Knowledge-Driven Interpretable Neural Networks for Mechanistic InsightSemantic proximity Read

Network modeling of patients' biomolecular profiles for clinical phenotype/outcome prediction.Semantic proximity Read