PINNet: a deep neural network with pathway prior knowledge for Alzheimer's disease

Abstract excerpt

Introduction Identification of Alzheimer's Disease (AD)-related transcriptomic signatures from blood is important for early diagnosis of the disease. Deep learning techniques are potent classifiers for AD diagnosis, but most have been unable to identify biomarkers because of their lack of interpretability. Methods To address these challenges, we propose a pathway information-based neural network (PINNet) to...

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