Article
Network modeling of patients' biomolecular profiles for clinical phenotype/outcome prediction.
Scientific reports - 27 Feb 2020
Gliozzo Jessica, Perlasca Paolo, Mesiti Marco, Casiraghi Elena, Vallacchi Viviana, Vergani Elisabetta, Frasca Marco, Grossi Giuliano, Petrini Alessandro, Re Matteo, Paccanaro Alberto, Valentini Giorgio
Abstract excerpt
Methods for phenotype and outcome prediction are largely based on inductive supervised models that use selected biomarkers to make predictions, without explicitly considering the functional relationships between individuals. We introduce a novel network-based approach named Patient-Net (P-Net) in which biomolecular profiles of patients are modeled in a graph-structured space that represents gene expression...
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