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Article

PathHDNN: a pathway hierarchical-informed deep neural network framework for predicting immunotherapy response and mechanism interpretation.

Genome medicine - 2 Dec 2025

Li Xiangmei, Pan Bingyue, He Yalan, Wang Ziyi, Tang Yujie, Zhang Yongbao, Wang Liqiang, Han Junwei

Abstract excerpt

BACKGROUND: Immunotherapy has revolutionized the treatment of cancer and tremendously prolonged the overall survival of patients; however, only parts of patients could derive durable clinical benefit from it. Predicting clinical responses to immunotherapy and interpreting the response mechanism remain major challenges. METHODS: Here, we presented a pathway hierarchical-informed deep neural network (PathHDNN)...

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Identifiers

PMID: 41327461
DOI: 10.1186/s13073-025-01584-9
PMCID: PMC12729056

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JAK2

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