Article

Insights into Renal Protein Handling Through GWAS of the Human Urine Proteome

2025-12-09

Abstract excerpt

The kidneys are an important determinant of circulating protein levels that retain plasma proteins at the glomerular filter and reclaim filtered proteins from urine. While genetic determinants of the circulating proteome have been extensively studied, studies of the urine proteome are lacking. We performed genome-wide association studies (GWAS) of 9 million common genetic variants for each of 2,868 proteins quanti...

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Literature Corpus work: 992f9b15-4544-5453-94fa-a070806d367c
DOI: 10.64898/2025.12.08.25341835

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