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Plasma Proteomics of Renal Function: A Transethnic Meta-Analysis and Mendelian Randomization Study

16 Jun 2021

Abstract excerpt

Significance Statement Studies on the plasma proteome of renal function have identified several biomarkers, but have lacked replication, were limited to European populations, and/or did not investigate causality with eGFR. Among four cohorts in a transethnic cross-sectional study, 57 plasma proteins were associated with eGFR, 23 of them also with CKD. Furthermore, Mendelian randomization and gene expression...

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PMID: 34135082
DOI: 10.1681/asn.2020071070

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