Article

The multiple sclerosis associated CD226 risk variant alters vitamin D-induced human type I regulatory T cell differentiation by impairing LFA-1 activation

2025-02-26

Abstract excerpt

<title>Abstract</title> <p>Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS), resulting from an intricate interplay between genetic predisposition and environmental factors. Vitamin D (VD) deficiency is one of the established risk factors for MS. CD46 costimulation of CD4+ T cells induces a switch from Th1 to type I regulatory cells (Tr1), characterized by increased IL-...

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Literature Corpus work: 991b774f-e78e-5535-938d-35dcbc768377
DOI: 10.21203/rs.3.rs-5475102/v1

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