A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus.

doi:10.1002/art.27677

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Article

A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus.

Arthritis and rheumatism - 1 Nov 2010

Löfgren Sara E, Delgado-Vega Angelica M, Gallant Caroline J, Sánchez Elena, Frostegård Johan, Truedsson Lennart, de Ramón Garrido Enrique, Sabio José M, González-Escribano María F, Pons-Estel Bernardo A, D'Alfonso Sandra, Witte Torsten, Lauwerys Bernard R, Endreffy Emoke, Kovács László, Vasconcelos Carlos, Martins da Silva Berta, Martín Javier, Alarcón-Riquelme Marta E, Kozyrev Sergey V

Abstract excerpt

OBJECTIVE: Costimulatory receptor CD226 plays an important role in T cell activation, differentiation, and cytotoxicity. This study was undertaken to investigate the genetic association of CD226 with susceptibility to systemic lupus erythematosus (SLE) and to assess the functional implications of...

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PMID: 20669283
DOI: 10.1002/art.27677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20669283-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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