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Article

A TLR/CD44 axis regulates T cell trafficking in experimental and human multiple sclerosis

11 Jan 2022

Abstract excerpt

In the pathogenesis of autoimmune disorders, the modulation of leukocytes 0 trafficking plays a central role, still poorly understood. Here, we focused on the effect of TLR2 ligands in trafficking of T helper cells through reshuffling of CD44 isoforms repertoire. Concurrently, strain background and TLR2 haplotype affected Wnt/b-catenin signaling pathway and expression of splicing factors. During EAE, mCD44 v9-v10...

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PMID: 35128357
DOI: 10.1016/j.isci.2022.103763

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