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Article

Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function.

Brain : a journal of neurology - 1 Nov 2015

Piédavent-Salomon Melanie, Willing Anne, Engler Jan Broder, Steinbach Karin, Bauer Simone, Eggert Britta, Ufer Friederike, Kursawe Nina, Wehrmann Sabine, Jäger Jan, Reinhardt Stefanie, Friese Manuel A

Abstract excerpt

Recent association studies have linked numerous genetic variants with an increased risk for multiple sclerosis, although their functional relevance remains largely unknown. Here we investigated phenotypical and functional consequences of a genetic variant in the CD226 gene that, among other autoimmune diseases, predisposes to multiple sclerosis. Phenotypically, effector and regulatory CD4(+) memory T cells of...

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Share to Antigens, Differentiation, T-Lymphocyte
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Share to Mice, Knockout

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Source

Identifiers

PMID: 26359290
DOI: 10.1093/brain/awv256

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function.PMID 26359290Read ↗

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