Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

Abstract excerpt

Cancer patients often experience changes in mental health, prompting an exploration into whether nerves infiltrating tumors contribute to these alterations by impacting brain functions. Using a mouse model for head and neck cancer and neuronal tracing we show that tumor-infiltrating nerves connect to distinct brain areas. The activation of this neuronal circuitry altered behaviors (decreased nest-building, increas...

Topics

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• Axon Guidance and Neuronal Signaling
• Cancer, Stress, Anesthesia, and Immune Response
• Fibromyalgia and Chronic Fatigue Syndrome Research
• Meningioma and schwannoma management
• Neurofibromatosis and Schwannoma Cases
• Pain Mechanisms and Treatments
• Vascular Malformations Diagnosis and Treatment

Identifiers and source

Literature Corpus work

991a7e82-0da1-57a7-8690-80e109747ba6

DOI

10.1101/2023.10.18.562990