Article

Divergent surgical outcomes for CACNA1D- and KCNJ5-mutant aldosteronomas are traceable to their cell-of-origin and most differentially expressed gene, CCM2L

2026-06-22

Abstract excerpt

<title>Abstract</title> <p>In a recent prospective trial in which adrenalectomy cured only 30% of 78 patients with apparently unilateral primary aldosteronism, somatic KCNJ5 and CACNA1D mutations of the aldosterone-producing adenoma (APA) had opposite influences on rates of biochemical and clinical success. We sought explanations in the bulk and single-cell gene expression profiles of the resected APAs. The most...

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Literature Corpus work: 98f58cf8-b4e3-58c1-876b-89607c284c0f
DOI: 10.21203/rs.3.rs-9942873/v1

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