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miR-1, miR-133a, miR-29b and skeletal muscle fibrosis in chronic limb-threatening ischaemia

26 Nov 2024

Abstract excerpt

Chronic limb-threatening ischaemia (CLTI), the most severe manifestation of peripheral arterial disease (PAD), is associated with a poor prognosis and high amputation rates. Despite novel therapeutic approaches being investigated, no significant clinical benefits have been observed yet. Understanding the molecular pathways of skeletal muscle dysfunction in CLTI is crucial for designing successful treatments. This...

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PMID: 39592654
DOI: 10.1038/s41598-024-76415-9

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