Article

Astrocytic TIMP-1 regulates production of Anastellin, a novel inhibitor of oligodendrocyte differentiation and FTY720 responses

2023-02-18

Abstract excerpt

Astrocyte activation is associated with neuropathology and the production of tissue inhibitor of metalloproteinase-1 (TIMP1). TIMP1 is a pleiotropic extracellular protein that functions both as a protease inhibitor and as a growth factor. We have previously demonstrated that murine astrocytes that lack expression of Timp1 do not support rat oligodendrocyte progenitor cell (rOPC) differentiation, and adult global...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98bd1583-8a0d-5c76-8347-72a760da4320
DOI: 10.1101/2023.02.17.529003

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Astrocytic TIMP-1 regulates production of Anastellin, a novel inhibitor of oligodendrocyte differentiation and FTY720 responsesDOI 10.1101/2023.02.17.529003Read

Injury-transduced SerpinOLs modulate neuroinflammation and glial activation in the diseased and non-diseased CNSSemantic proximity Read

The TIMP protein family: diverse roles in pathophysiologySemantic proximity Read

Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In VivoSemantic proximity Read

A Unique TGFB1-Driven Genomic Program Links Astrocytosis, Low-Grade Inflammation and Partial Demyelination in Periplaques of Spinal Cords from Progressive Multiple Sclerosis PatientsSemantic proximity Read

Youth-associated protein TIMP2 alters microglial state and function in the context of agingSemantic proximity Read

Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion.Semantic proximity Read

TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T CellsSemantic proximity Read

Dysregulation of the MMP/TIMP Proteolytic System in Subependymal Giant Cell Astrocytomas in Patients With Tuberous Sclerosis Complex: Modulation of MMP by MicroRNA-320d In VitroSemantic proximity Read

TIMP1 secretion induced by Toxoplasma effector GRA24 via p38 MAPK signaling promotes non-disruptive parasite translocation across polarized brain endothelial monolayersSemantic proximity Read

Pathogenesis of myelin/oligodendrocyte damage in multiple sclerosisSemantic proximity Read

Interleukin-33 from oligodendrocytes sustains effector differentiation of tissue-resident CD8+ T cells and is a druggable target in CNS autoimmune diseaseSemantic proximity Read

Astrocytic activation of EMMPRIN contributes to their pathological phenotype in ALSSemantic proximity Read