TIMP1 secretion induced by Toxoplasma effector GRA24 via p38 MAPK signaling promotes non-disruptive parasite translocation across polarized brain endothelial monolayers

Abstract excerpt

ABSTRACT The protozoan Toxoplasma gondii first crosses the intestinal wall and then the blood–brain barrier (BBB) to establish chronic, latent infections in humans and other warm-blooded vertebrates. However, the molecular mechanisms underlying this stealthy colonization remain poorly understood. In this study, we investigated the passage of T. gondii tachyzoites across polarized monolayers of murine brain...

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