Article

Astrocytic activation of EMMPRIN contributes to their pathological phenotype in ALS

2025-02-25

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterised by the degeneration of upper and lower motoneurons. Onset and progression of the disease are determined by both cell-autonomous neuronal dysfunctions and non-cell-autonomous factors, mainly due to activation of glial cells such as astrocytes and microglia. The Extracellular Matrix Metalloproteinases INducer (EMMPRIN), a glycoprotein expressed by...

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Literature Corpus work: 0957e527-1b1b-58da-9029-d179cb0ba11c
DOI: 10.1101/2025.02.23.639749

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