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Article

Pathogenesis of myelin/oligodendrocyte damage in multiple sclerosis

29 May 2007

Abstract excerpt

Substantial evidence supports autoimmune activity as the etiologic mechanism underlying multiple sclerosis (MS). Both the innate and the adaptive arms of the immune system are involved in the aberrant response to several antigens associated with the myelin sheath and oligodendrocytes (OGCs) after the activation of immune cells by self- or cross-reactive microbial pathogens. The CD4(+) Th1 cell, in particular, has...

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PMID: 17548563
DOI: 10.1212/01.wnl.0000275228.13012.7b

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