Article
Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice.
Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013
Berbari Nicolas F, Pasek Raymond C, Malarkey Erik B, Yazdi S M Zaki, McNair Andrew D, Lewis Wesley R, Nagy Tim R, Kesterson Robert A, Yoder Bradley K
Abstract excerpt
Although primary cilia are well established as important sensory and signaling structures, their function in most tissues remains unknown. Obesity is a feature associated with some syndromes of cilia dysfunction, such as Bardet-Biedl syndrome (BBS) and Alström syndrome, as well as in several cilia mutant mouse models. Recent data indicate that obesity in BBS mutant mice is due to defects in leptin receptor...
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