Article

Single-nuclear RNA sequencing of endomyocardial biopsies identifies persistence of donor-recipient chimerism with distinct signatures in severe cardiac allograft vasculopathy

2022-08-26

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac allograft vasculopathy (CAV) is the leading cause of late allograft failure and mortality after heart transplantation. As current standards of diagnosis and treatment of CAV have significant limitations, understanding cell-specific responses may prove critical for developing improved detection strategies and novel therapeutics. This study is the first to successfully utilize human endomy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f2e9300-ba49-5640-b52b-cc26a1daecc1
DOI: 10.1101/2022.08.24.504346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-nuclear RNA sequencing of endomyocardial biopsies identifies persistence of donor-recipient chimerism with distinct signatures in severe cardiac allograft vasculopathyDOI 10.1101/2022.08.24.504346Read

Comparing Plasma Donor–derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart StudySemantic proximity Read

Endothelial PTBP1 Deletion in Transplanted Cardiac Tissue Limits Cardiac Allograft VasculopathySemantic proximity Read

Advancing Nuclei Isolation from Frozen Human Heart for Single-Nucleus RNA Sequencing ApplicationsSemantic proximity Read

Rejection Surveillance: Integrating Cell-Free DNA and Gene Expression Panels to Decrease Invasiveness in Routine Monitoring of Heart Transplant RecipientsSemantic proximity Read

A Method for Cryopreservation and Single Nucleus RNA-sequencing of Normal Adult Human Interventricular Septum Heart Tissue Reveals Cellular Diversity and FunctionSemantic proximity Read

Transcriptional and Cellular Diversity of the Human HeartSemantic proximity Read

Relationship Between Donor Derived Cell-Free DNA and Tissue-Based Rejection-Related Transcripts In Heart TransplantationSemantic proximity Read

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failureSemantic proximity Read

Integrated Molecular Profiling of Preclinical and Clinical Cardiac XenotransplantsSemantic proximity Read

Single Cell and Spatial Transcriptomics Identify Novel Immune-Stromal Interactions in Cardiac Allograft VasculopathySemantic proximity Read

Single Cell Transcriptomics Reveals Cell Type Specific Diversification in Human Heart FailureSemantic proximity Read

Single cell transcriptomic analyses of human heart failure with preserved ejection fractionSemantic proximity Read