Article

Production of recombinant human acid α-glucosidase with mannosidic N-glycans in α-mannosidase I mutant rice cell suspension culture

2022-02-07

Abstract excerpt

High-mannose glycans, containing 6-9 mannose residues, are favorable for in vitro mannose phosphorylation to produce Mannose-6-phosphate (M6P) residues. These are important for lysosomal enzyme targeting and essential for uptake. Golgi α-mannosidase-I mediates mannose trimming in the N-glycosylation pathway. In this study, I used mutant rice with a T-DNA insertion in the Os04g0606400 (Δ α-man I) gene to produce...

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Literature Corpus work: 98af382d-1c44-5ea8-afd1-e117aa67f12e
DOI: 10.1101/2022.02.07.479152

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