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Article

Compensatory expression of human N-acetylglucosaminyl-1-phosphotransferase subunits in mucolipidosis type III gamma.

Biochimica et biophysica acta - 1 Mar 2009

Pohl Sandra, Tiede Stephan, Castrichini Monica, Cantz Michael, Gieselmann Volkmar, Braulke Thomas

Abstract excerpt

The N-Acetylglucosaminyl-1-phosphotransferase plays a key role in the generation of mannose 6-phosphate (M6P) recognition markersessential for efficient transport of lysosomal hydrolases to lysosomes. The phosphotransferase is composed of six subunits (alpha2, beta2, gamma2). The alpha- and beta-subunits are catalytically active and encoded by a single gene, GNPTAB, whereas the gamma-subunit encoded by GNPTG is...

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Source

Identifiers

PMID: 19708128
DOI: 10.1016/j.bbadis.2009.01.009

Genes

GNPTAB
GNPTG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Compensatory expression of human N-acetylglucosaminyl-1-phosphotransferase subunits in mucolipidosis type III gamma.PMID 19708128Read ↗

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