Article

miR-21 blocks obesity in mice: a potential therapy for humans

2020-10-31

Abstract excerpt

microRNAs are promising drug targets in obesity and metabolic disorders. miR-21 expression is upregulated in obese white adipose tissue (WAT); however, its physiological role in WAT has not been fully explored. We aimed to dissect the underlying molecular mechanisms of miR-21 in treating obesity, diabetes, and insulin resistance. We demonstrated, in human and mice, that elevated miR-21 expression is associated wit...

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Literature Corpus work: 7c342794-7073-566c-897b-6cf5f272bab4
DOI: 10.1101/2020.10.27.20219915

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