Article

A recurring YYDRxG pattern in broadly neutralizing antibodies to a conserved site on SARS-CoV-2, variants of concern, and related viruses

2021-12-17

Abstract excerpt

<h4>ABSTRACT</h4> Studying the antibody response to SARS-CoV-2 informs on how the human immune system can respond to antigenic variants as well as other SARS-related viruses. Here, we structurally and functionally characterized a potent human antibody ADI-62113 that also neutralizes SARS-CoV- 2 variants of concern and cross-reacts with many other sarbecoviruses. A YYDRxG motif encoded by IGHD3-22 in CDR H3 facil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 989f4747-017c-513d-bd7f-af44a067b878
DOI: 10.1101/2021.12.15.472864

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A recurring YYDRxG pattern in broadly neutralizing antibodies to a conserved site on SARS-CoV-2, variants of concern, and related virusesDOI 10.1101/2021.12.15.472864Read

Human antibodies to SARS-CoV-2 with a recurring YYDRxG motif retain binding and neutralization to variants of concern including OmicronSemantic proximity Read

The D Gene in CDR H3 Determines a Public Class of Human Antibodies to SARS-CoV-2Semantic proximity Read

A broadly neutralizing antibody recognizing a unique epitope with signature motif common across coronaviral familiesSemantic proximity Read

Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2Semantic proximity Read

Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognitionSemantic proximity Read

A population antibody response against SARS-CoV-2 with differential neutralization activities towards the Delta and Omicron variantsSemantic proximity Read

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2Semantic proximity Read

Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2Semantic proximity Read

The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2Semantic proximity Read

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infectionSemantic proximity Read

A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variantsSemantic proximity Read

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19Semantic proximity Read