Article

A broadly neutralizing antibody recognizing a unique epitope with signature motif common across coronaviral families

2025-02-11

Abstract excerpt

<title>Abstract</title> <p>Cross-reactive antibodies that bind to diverse epitopes have been identified in Sarbecoviruses, but the precise molecular mechanisms remain poorly understood. This study describes the isolation of a broadly neutralizing monoclonal antibody, 3D1, derived from a fully human combinatorial antibody library that targets the highly conserved HR1 domain of Sarbecoviruses. 3D1 uniquely recogniz...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78d9d929-1fc1-57cf-a5cc-48ee07a0262a
DOI: 10.21203/rs.3.rs-5856104/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A broadly neutralizing antibody recognizing a unique epitope with signature motif common across coronaviral familiesDOI 10.21203/rs.3.rs-5856104/v1Read

A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronavirusesSemantic proximity Read

A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversificationSemantic proximity Read

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2Semantic proximity Read

Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognitionSemantic proximity Read

A recurring YYDRxG pattern in broadly neutralizing antibodies to a conserved site on SARS-CoV-2, variants of concern, and related virusesSemantic proximity Read

Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2Semantic proximity Read

A population antibody response against SARS-CoV-2 with differential neutralization activities towards the Delta and Omicron variantsSemantic proximity Read

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infectionSemantic proximity Read

Novel neutralization mechanism of a human antibody with pan-coronavirus reactivitySemantic proximity Read

Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2Semantic proximity Read

Broadly-Neutralizing Antibodies Against Emerging SARS-CoV-2 Variants.Semantic proximity Read

Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient ResponsesSemantic proximity Read