Article

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2

2022-11-28

Abstract excerpt

Emergence of SARS-CoV-2 variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens resilient to viral evolution is therefore necessary. Using coldspot-guided antibody discovery, a screening approach that focuses on portions of the virus spike that are both functionally relevant and averse to change, we identified human neutraliz...

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Identifiers and source

Literature Corpus work: 59b64119-d668-5882-a1ad-d7545fbd0227
DOI: 10.1101/2022.11.24.515932

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