Article

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

2020-11-17

Abstract excerpt

The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores the need for broadly active countermeasures. Here, we employed a directed evolution approach to engineer three SARS-CoV-2 antibodies for enhanced neutralization breadth and potency. One of the affinity-matured variants, ADG-2, displays strong binding activity to a large panel of sarbecovirus receptor binding domains (RBD...

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Literature Corpus work: ce1a64fa-2664-5929-91d6-db4386e9b542
DOI: 10.1101/2020.11.17.385500

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