Article

Prosaposin is cleaved into saposins by multiple cathepsins in a progranulin-regulated fashion

2024-02-16

Abstract excerpt

Prosaposin (PSAP) is a lysosomal protein that plays a key role in sphingolipid metabolism. PSAP is cleaved into four bioactive disulfide-rich peptides, saposins A, B, C, and D, that catalyze sphin-golipidases to promote sphingolipid breakdown. Considering the key role of PSAP and saposins in sphingolipid metabolism and the existence of genetic mutations in PSAP associated with juve-nile-onset lysosomal storage and...

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Identifiers and source

Literature Corpus work: 98955432-cda5-5279-aea4-487831a3e6dd
DOI: 10.1101/2024.02.15.580326

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