Article
Single-nucleotide variant calling in single-cell sequencing data with Monopogen.
Nature biotechnology - 1 May 2024
Dou Jinzhuang, Tan Yukun, Kock Kian Hong, Wang Jun, Cheng Xuesen, Tan Le Min, Han Kyung Yeon, Hon Chung-Chau, Park Woong-Yang, Shin Jay W, Jin Haijing, Wang Yujia, Chen Han, Ding Li, Prabhakar Shyam, Navin Nicholas, Chen Rui, Chen Ken
Abstract excerpt
Single-cell omics technologies enable molecular characterization of diverse cell types and states, but how the resulting transcriptional and epigenetic profiles depend on the cell's genetic background remains understudied. We describe Monopogen, a computational tool to detect single-nucleotide variants (SNVs) from single-cell sequencing data. Monopogen leverages linkage disequilibrium from external reference...
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