Article

Whole genome sequencing of pre-treatment and post-treatment locally advanced rectal cancer using long and short read technologies

2025-12-12

Abstract excerpt

<h4>ABSTRACT</h4> We performed Illumina short-read and nanopore (ONT) whole genome sequencing (WGS) on samples obtained from a 37-year-old patient with locally advanced rectal cancer who did not respond to neoadjuvant chemoradiotherapy (nCRT). Pre-treatment and post-nCRT tumour biopsy, adjacent normal tissue, and matched pre-treatment blood samples were sequenced to identify somatic alterations. We used DNA methy...

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Literature Corpus work: 9869744c-b8c3-58e5-826b-f68e1412cb27
DOI: 10.64898/2025.12.12.693949

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