Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular predictors of treatment resistance and recurrence following neoadjuvant therapy in rectal cancer.

BMC cancer - 22 Oct 2025

Huang Fengyuan, McLeod M Chandler, Irwin Regina K, Smithson Mary, Gao Min, Hardiman Karin M, Chong Zechen

Abstract excerpt

Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer, but only 20–40% of patients completely respond to this treatment. Pre-treatment predictors of response are understudied. To define the molecular features that are associated with response to nCRT, we compared genomic and transcriptomic data from 318 pre-treatment biopsies of microsatellite stable rectal cancers from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Neoplastic

Share to Neoadjuvant Therapy

Share to Neoplasm Recurrence, Local

Share to Rectal Neoplasms

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 41126128
DOI: 10.1186/s12885-025-14958-4
PMCID: PMC12542088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular predictors of treatment resistance and recurrence following neoadjuvant therapy in rectal cancer.PMID 41126128Read ↗

Molecular differentiation between complete and incomplete responders to neoadjuvant therapy in rectal cancerSemantic proximity Read ↗

Increased Levels of Genomic Instability and Mutations in Homologous Recombination Genes in Locally Advanced Rectal CarcinomasSemantic proximity Read ↗

Identification of a biomarker profile associated with resistance to neoadjuvant chemoradiation therapy in rectal cancer.Semantic proximity Read ↗

Clinical and genetic factors associated with tumor response to neoadjuvant (chemo)radiotherapy, survival and recurrence risk in rectal cancer.Semantic proximity Read ↗

A Genotype Signature for Predicting Pathologic Complete Response in Locally Advanced Rectal Cancer.Semantic proximity Read ↗

Genetic Determinants of Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer Identified by Whole Exome Sequencing.Semantic proximity Read ↗

The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.Semantic proximity Read ↗

KRASG12V/A146T mutations are associated with nCRT resistance via enhanced DNA double-strand break repair and support a deep learning prediction framework in LARC.Semantic proximity Read ↗

Predictive and Prognostic Molecular Biomarkers for Response to Neoadjuvant Chemoradiation in Rectal Cancer.Semantic proximity Read ↗

Pre-Existing Tumoral B Cell Infiltration and Impaired Genome Maintenance Correlate with Response to Chemoradiotherapy in Locally Advanced Rectal CancerSemantic proximity Read ↗

Exploring novel inflammation-related genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancerSemantic proximity Read ↗

Gene expression profile is associated with chemoradiation resistance in rectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.