Article

Identification of differential nutrient starvation responses

2018-01-01

Abstract excerpt

To promote survival and proliferation cancer cells re-programme their metabolism, altering both uptake and utilisation of extracellular nutrients. To examine correspondences between nutrient supply and viability, in order to identify targetable requirements, I individually depleted amino acid nutrients from diploid Human Mammary Epithelial (HME) isogenic cells expressing commonly activated oncogenes. Cystine depri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 984fcb00-648f-5b5a-8ac8-66a5c05781d2
DOI: 10.17638/03019213

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of differential nutrient starvation responsesDOI 10.17638/03019213Read

Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine.Semantic proximity Read

Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling.Semantic proximity Read

Ferroptosis vulnerability in MYCN‐driven neuroblastomasSemantic proximity Read

Systematic Evaluation Defines the Limits of Ferroptosis in Cancer TherapySemantic proximity Read

Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosisSemantic proximity Read

Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics studySemantic proximity Read

Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer CellsSemantic proximity Read

NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cellsSemantic proximity Read

Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosisSemantic proximity Read

Metabolic vulnerability of cisplatin‐resistant cancersSemantic proximity Read

“Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import”Semantic proximity Read

Metabolic stress induces GD2+ cancer stem cell-like phenotype in triple-negative breast cancer.Semantic proximity Read