“Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import”

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is the third-leading cause of cancer mortality in the US and is highly resistant to classical, targeted, and immune therapies. We show that human PDA cells are dependent on the provision of exogenous cystine to avert a catastrophic accumulation of lipid reactive oxygen species (ROS) that, left unchecked, leads to ferroptotic cell death, both in vitro and in vivo . Using a d...

Topics

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• Breast
• Carcinoma, Pancreatic Ductal
• Cell Death
• Epigenetics and DNA Methylation
• Ferroptosis
• Ferroptosis and cancer prognosis
• Mutation
• Pancreatic Neoplasms

Identifiers and source

Literature Corpus work

ba1595a2-611f-5e0d-972a-d937aa23a77d

DOI

10.1101/827972