Article

Role of TPM2 in Pediatric Restrictive Cardiomyopathy: Insights from Single-Nucleus RNA Sequencing and Proteomic Analysis

2025-08-05

Abstract excerpt

Restrictive cardiomyopathy (RCM) is an uncommon pediatric condition characterised by diastolic dysfunction caused by myocardial stiffness, with preserved systolic function in the early stage. Its pathogenesis is linked to genetic mutations, metabolic defects, or fibrosis, but this process remains incompletely understood. Bioinformatics analysis indicated a crucial role of tropomyosin 2 (TPM2) in pediatric RCM. Usi...

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Literature Corpus work: 5e757802-5828-56f8-adf6-aef1ba123d43
DOI: 10.1101/2025.08.01.25332843

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