Article

Lineage-specific regulatory changes in the pathological cardiac remodeling of hypertrophy cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics

2021-07-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Hypertrophy cardiomyopathy (HCM) is the most common cardiac genetic disorder with the histopathological features of cardiomyocyte hypertrophy and cardiac fibrosis. The pathological remodeling that occurs in the myocardium of HCM patients may ultimately progress to heart failure and death. A thorough understanding of the cell type-specific changes in the pathological cardiac...

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Literature Corpus work: e1c03ce0-374d-5f36-bdda-0e1ae82cb342
DOI: 10.1101/2021.07.21.453191

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