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Article

Nrf2: A unifying transcription factor in the pathogenesis of Fuchs’ endothelial corneal dystrophy

1 Oct 2020

Abstract excerpt

Nuclear factor, erythroid 2 like 2 (Nrf2), is an oxidative stress induced transcription factor that regulates cytoprotective gene expression. Thus, Nrf2 is essential for cellular redox homeostasis. Loss or dysregulation of Nrf2 expression has been implicated in the pathogenesis of degenerative diseases, including diseases of the cornea. One of the most common diseases of the cornea in which Nrf2 is implicated is...

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PMID: 33099215
DOI: 10.1016/j.redox.2020.101763

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