Article

Human melanoma cell lines that possess wild-type <i>BRAF</i> alleles but are dependent on <i>ERBB4</i> and <i>ERBB2</i>

2024-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic skin cutaneous melanomas that contain wild-type BRAF alleles typically possess an activating mutation in a RAS allele or a loss-of-function mutation in an NF1 allele (“ BRAF -WT& RAS / NF1- mutant melanomas”). Nonetheless, these tumors remain a significant clinical challenge; they are resistant to MEK and BRAF inhibitors, their response to immune checkpoint inhibitors is less ro...

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Literature Corpus work: 97fa1360-c201-5520-9a8e-42deb61a439c
DOI: 10.1101/2024.08.22.609260

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